髓鞘少突胶质细胞糖蛋白(MoG35-55)诱导的实验性自身免疫性脑脊髓炎(EAE)是MS经典动物模型， 多发性硬化(multiple sclerosis，MS)是中枢神经系统(CNS)慢性炎症性脱髓鞘性疾病，其确切发病机制尚不清楚。目前所使用的MOG多为商业合成肽段MOG35-55，MOG35-55是髓鞘少突胶质细胞糖蛋白myelin oligodendrocyte glycoprotein,的第35-55位片段MEVGWYRSPFSRVVHLYRNGK,存在于髓鞘膜和少突胶质细胞的最外层,故具有高度免疫原，其基本信息如下：
MOG35-55;MOG（35-55 ）髓鞘少突胶质细胞糖蛋白(MoG35-55)
MOG(35-55),MOG35-55,MOG 35-55,Myelin Oligodendrocyte Glycoprotein(35-55),
Myelin Oligodendrocyte Glycoprotein35-55,Myelin Oligodendrocyte Glycoprotein 35-55
Single letter code: MEVGWYRPPFSRVVHLYRNGK
Single letter code: NH2-MEVGWYRPPFSRVVHLYRNGK-COOH
Triple letter code: NH2- Met - Glu - Val - Gly - Trp - Tyr - Arg - Pro - Pro - Phe - Ser - Arg - Val - Val - His - Leu - Tyr - Arg - Asn - Gly - Lys -COOH
Number of residues:21
Molecular weight: 2591.99 g/mol
Extinction coefficient: 8250 M-1cm-1
Iso-electric point: pH 10.58
Net charge at pH 7:3.1
Estimated solubility: Good water solubility.
我公司可以提供的其他常见的MOG产品如下：
| APG2659 | MOG(35 - 52) | MEVGWYRSPFSRVVHLYR |
| APG2658 | MOG (97 - 108) | TCFFRDHSYQEE |
| APG2657 | MOG (96 - 108), human | TCFFRDHSYQSEA |
| APG2656 | MOG (94 - 110), human | GFTCFFRDHSYQEEAAM |
| APG2655 | MOG (92–106) | DEGGYTCFFRDHSYQ |
| APG2654 | MOG (91 - 108), rat | SDEGGYTCFFRDHSYQEE |
| APG2652 | MOG (8 - 22), rat | PGYPIRALVGDEQED |
| APG2653 | MOG (89-113) human | RFSDEGGFTCFFRDHSYQEEAAMEL |
| APG2651 | MOG (8 - 21) | PGYPIRALVGDEAE |
| APG2650 | MOG (79 - 96) | GKVALRIQNVRFSDEGGY |
| APG2649 | MOG (76-100), human | IGEGKVTLRIRNVRFSDEGGFTCFF |
| APG2648 | MOG (71 - 90), mouse | LLKETISEGKVTLRIQNVRF |
| APG2647 | MOG (67-87), rat | GRTELLKESIGEGKVALRIQN |
| APG2645 | MOG (46 - 54) | RVVHLYRNG |
| APG2646 | MOG (50 - 74), human | LYRNGKDQDGDAPEYRGRTELLKD |
| APG2644 | MOG (45 - 54) | SRVVHLYRNG |
| APG2643 | MOG (43–54) | PFSRVVHLYRNG |
| APG2642 | MOG (42 - 54) | SPFSRVVHLYRNG |
| APG2641 | MOG (41–54) | RSPFSRVVHLYRNG |
| APG2640 | MOG (40–55) | YRSPFSRVVHLYRNGK |
| APG2639 | MOG (40–54) | YRSPFSRVVHLYRNG |
| APG2638 | MOG (38-60), human | GWYRPPFSRVVHLYRNGKDQDGD |
| APG2637 | MOG (38–53) | GWYRSPFSRVVHLYRN |
| APG2635 | MOG (35 - 55) mouse rat | MEVGWYRSPFSRVVHLYRNGK |
| APG2636 | MOG (38 - 55) | GWYRSPFSRVVHLYRNGK |
| APG2634 | MOG (35 - 55) mouse rat (12668-10) | MEVGWYRSPFSRVVHLYRNGK |
| APG2633 | MOG (35 - 55) mouse rat (12668-05) | MEVGWYRSPFSRVVHLYRNGK |
| APG2632 | MOG (35 - 55) human | MEVGWYRPPFSRVVHLYRNGK |
| APG2631 | MOG (35 - 53) | MEVGWYRSPFSRVVHLYRN |
| APG2630 | MOG (35 - 51) | MEVGWYRSPFSRVVHLY |
| APG2629 | MOG (27 - 50), human | SPGKNATGMELGWYRPPFSRVVHL |
| APG2628 | MOG (14 - 39) | ALVGDEVELPCRISPGKNATGMELGW |
| APG2627 | MOG (1-21), rat | GQFRVIGPGHPIRALVGDEAE |
| APG2626 | MOG (101 - 120), human, mouse | RDHSYQEEAAMELKVEDPFY |
| APG2625 | MOG (1 - 26), human | GQFRVIGPRHPIRALVGDEVELPCRI |
如需要如上产品请联系我公司客服。
参考文章：MOG诱导实验性自身免疫性脑脊髓炎小鼠模型的建立- 温州医学院附属**医院神经内科 李佳等
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